Pamela J. Focia : rechercher sur Z-Library

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Structure of a GDP:AlF4 Complex of the SRP GTPases Ffh and FtsY, and Identification of a Peripheral Nucleotide Interaction Site

Pamela J. Focia, Joseph Gawronski-Salerno, John S. Coon V, Douglas M. Freymann

Journal:

Journal of Molecular Biology

Année:

2006

Langue:

english

Fichier:

PDF, 733 KB

english, 2006

An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury

Anastasia V. Velentza, Mark S. Wainwright, Magdalena Zasadzki, Salida Mirzoeva, Andrew M. Schumacher, Jacques Haiech, Pamela J. Focia, Martin Egli, D.Martin Watterson

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 258 KB

english, 2003

Efficient identification of inhibitors targeting the closed active site conformation of the HPRT from Trypanosoma cruzi

Douglas M Freymann, Mary Anne Wenck, Juan C Engel, Jun Feng, Pamela J Focia, Ann E Eakin, Sydney P Craig III

Journal:

Chemistry & Biology

Année:

2000

Langue:

english

Fichier:

PDF, 840 KB

english, 2000

Novel protein and Mg2+ configurations in the Mg2+GDP complex of the SRP GTPase ffh

Pamela J. Focia, Hena Alam, Thanh Lu, Ursula D. Ramirez, Douglas M. Freymann

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

2004

Langue:

english

Fichier:

PDF, 347 KB

english, 2004

X-ray structure of the T. Aquaticus Ftsy:GDP complex suggests functional roles for the C-terminal helix of the SRP GTPases

Joseph Gawronski-Salerno, John S. Coon V, Pamela J. Focia, Douglas M. Freymann

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

2007

Langue:

english

Fichier:

PDF, 1.11 MB

english, 2007

Cu(I) recognition via cation-π and methionine interactions in CusF

Xue, Yi, Davis, Anna V, Balakrishnan, Gurusamy, Stasser, Jay P, Staehlin, Benjamin M, Focia, Pamela, Spiro, Thomas G, Penner-Hahn, James E, O'Halloran, Thomas V

Journal:

Nature Chemical Biology

Année:

2007

Langue:

english

Fichier:

PDF, 340 KB

english, 2007

Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions

Chen, Xiaoyan, Liu, Heli, Shim, Ann H R, Focia, Pamela J, He, Xiaolin

Journal:

Nature Structural and Molecular Biology

Année:

2007

Langue:

english

Fichier:

PDF, 678 KB

english, 2007

Structural basis of TEA blockade in a model potassium channel

Lenaeus, Michael J, Vamvouka, Magdalini, Focia, Pamela J, Gross, Adrian

Journal:

Nature Structural and Molecular Biology

Année:

2005

Langue:

english

Fichier:

PDF, 725 KB

english, 2005

Structural basis for stem cell factor–KIT signaling and activation of class III receptor tyrosine kinases

Liu, Heli, Chen, Xiaoyan, Focia, Pamela J, He, Xiaolin

Journal:

The EMBO Journal

Année:

2007

Langue:

english

Fichier:

PDF, 644 KB

english, 2007

Ternary complex structure of human hgprtase, prpp, mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding

Ganesaratnam K. Balendiran, JOSÉ A. Molina, Yiming Xu, Jan Torres-Martinez, Robert Stevens, Pamela J. Focia, Ann E. Eakin, James C. Sacchettini, Sydney P. Craig III

Journal:

Protein Science

Année:

1999

Langue:

english

Fichier:

PDF, 469 KB

english, 1999

Structures of Ceftazidime and Its Transition-State Analogue in Complex with AmpC β-Lactamase: Implications for Resistance Mutations and Inhibitor Design†,‡

Powers, Rachel A., Caselli, Emilia, Focia, Pamela J., Prati, Fabio, Shoichet, Brian K.

Journal:

Biochemistry

Année:

2001

Langue:

english

Fichier:

PDF, 359 KB

english, 2001

Substitution of lysine for arginine at position 199 of a hypoxanthine phosphoribosyltransferase interferes with binding of the primary substrate to the active site

Sydney P Craig III, Pamela J Focia, Robert J Fletterick

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

1997

Langue:

english

Fichier:

PDF, 241 KB

english, 1997

Limited proteolysis of a trypanosomal hypoxanthine phosphoribosyltransferase yields crystals that diffract X-rays to near atomic resolution

René Nieves-Alicea, Pamela J. Focia, Sydney P. Craig III, Ann E. Eakin

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

1998

Langue:

english

Fichier:

PDF, 181 KB

english, 1998

Structural Milestones in the Reaction Pathway of an Amide Hydrolase: Substrate, Acyl, and Product Complexes of Cephalothin with AmpC β-Lactamase

Beth M Beadle, Indi Trehan, Pamela J Focia, Brian K Shoichet

Journal:

Structure

Année:

2002

Langue:

english

Fichier:

PDF, 438 KB

english, 2002

Erratum

Beth M Beadle, Indi Trehan, Pamela J Focia, Brian K Shoichet

Journal:

Structure

Année:

2002

Fichier:

PDF, 15 KB

2002

Structural Basis of Semaphorin-Plexin Recognition and Viral Mimicry from Sema7A and A39R Complexes with PlexinC1

Heli Liu, Z. Sean Juo, Ann Hye-Ryong Shim, Pamela J. Focia, Xiaoyan Chen, K. Christopher Garcia, Xiaolin He

Journal:

Cell

Année:

2010

Langue:

english

Fichier:

PDF, 2.25 MB

english, 2010

Interactions at the Dimer Interface Influence the Relative Efficiencies for Purine Nucleotide Synthesis and Pyrophosphorolysis in a Phosphoribosyltransferase

Bhutorn Canyuk, Francisco J. Medrano, Mary Anne Wenck, Pamela J. Focia, Ann E. Eakin, Sydney P. Craig III

Journal:

Journal of Molecular Biology

Année:

2004

Langue:

english

Fichier:

PDF, 2.03 MB

english, 2004

Structural Basis for Mobility in the 1.1 Å Crystal Structure of the NG Domain of Thermus aquaticus Ffh

Ursula D. Ramirez, George Minasov, Pamela J. Focia, Robert M. Stroud, Peter Walter, Peter Kuhn, Douglas M. Freymann

Journal:

Journal of Molecular Biology

Année:

2002

Langue:

english

Fichier:

PDF, 847 KB

english, 2002

Electron Spin-Echo Envelope Modulation (ESEEM) Reveals Water and Phosphate Interactions with the KcsA Potassium Channel ,

Cieslak, John A., Focia, Pamela J., Gross, Adrian

Journal:

Biochemistry

Année:

2010

Langue:

english

Fichier:

PDF, 3.25 MB

english, 2010

Miro: A Driver of the Kinesin Motor

Klosowiak, Julian L., Focia, Pamela J., Gonzalez, Melissa C., Sato, Colin, Freymann, Douglas M., Rice, Sarah E.

Journal:

Biophysical Journal

Année:

2013

Langue:

english

Fichier:

PDF, 39 KB

english, 2013

Structural Coupling of the EF Hand and C-Terminal GTPase Domains in the Mitochondrial Protein Miro

Klosowiak, Julian, Focia, Pamela, Chakravarthy, Srinivas, Landahl, Eric, Freymann, Douglas, Rice, Sarah

Journal:

Biophysical Journal

Année:

2014

Langue:

english

Fichier:

PDF, 41 KB

english, 2014

Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro

Klosowiak, Julian L, Focia, Pamela J, Chakravarthy, Srinivas, Landahl, Eric C, Freymann, Douglas M, Rice, Sarah E

Journal:

EMBO reports

Année:

2013

Langue:

english

Fichier:

PDF, 413 KB

english, 2013

A 1.4 Å Crystal Structure for the Hypoxanthine Phosphoribosyltransferase of Trypanosoma c ruzi †,⊥

Focia, Pamela J., Craig, Sydney P., Nieves-Alicea, René, Fletterick, Robert J., Eakin, Ann E.

Journal:

Biochemistry

Année:

1998

Langue:

english

Fichier:

PDF, 188 KB

english, 1998

Crystal Structure of the Hypoxanthine−Guanine−Xanthine Phosphoribosyltransferase from the Protozoan Parasite Tritrichomonas foetus †,‡

Somoza, John R., Chin, Marian S., Focia, Pamela J., Wang, Ching C., Fletterick, Robert J.

Journal:

Biochemistry

Année:

1996

Langue:

english

Fichier:

PDF, 542 KB

english, 1996

Approaching the Transition State in the Crystal Structure of a Phosphoribosyltransferase †,‡

Focia, Pamela J., Craig, Sydney P., Eakin, Ann E.

Journal:

Biochemistry

Année:

1998

Langue:

english

Fichier:

PDF, 146 KB

english, 1998

Structures of KcsA in Complex with Symmetrical Quaternary Ammonium Compounds Reveal a Hydrophobic Binding Site

Lenaeus, Michael J., Burdette, Dylan, Wagner, Tobias, Focia, Pamela J., Gross, Adrian

Journal:

Biochemistry

Année:

2014

Langue:

english

Fichier:

PDF, 4.83 MB

english, 2014

The Role for an Invariant Aspartic Acid in Hypoxanthine Phosphoribosyltransferases Is Examined Using Saturation Mutagenesis, Functional Analysis, and X-ray Crystallography †

Canyuk, Bhutorn, Focia, Pamela J., Eakin, Ann E.

Journal:

Biochemistry

Année:

2001

Langue:

english

Fichier:

PDF, 513 KB

english, 2001

Nanomolar Inhibitors of AmpC β-Lactamase

Morandi, Federica, Caselli, Emilia, Morandi, Stefania, Focia, Pamela J., Blázquez, Jesús, Shoichet, Brian K., Prati, Fabio

Journal:

Journal of the American Chemical Society

Année:

2003

Langue:

english

Fichier:

PDF, 390 KB

english, 2003

Identification of the Active Sites of Human and Schistosomal Hypoxanthine-Guanine Phosphoribosyltransferases by GMP-2',3'-dialdehyde Affinity Labeling

Kanaani, Jamil, Maltby, David, Focia, Pamela, Wang, Ching C.

Journal:

Biochemistry

Année:

1995

Langue:

english

Fichier:

PDF, 2.67 MB

english, 1995

Structures of Human Miro1 Reveal Conformational Changes

Klosowiak, Julian, Focia, Pamela, Chakravarthy, Srinivas, Freymann, Douglas, Rice, Sarah

Journal:

Biophysical Journal

Année:

2015

Langue:

english

Fichier:

PDF, 41 KB

english, 2015

Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex

Ann Hye-Ryong Shim, Heli Liu, Pamela J. Focia, Xiaoyan Chen, P. Charles Lin and Xiaolin He

Journal:

Proceedings of the National Academy of Sciences

Année:

2010

Langue:

english

Fichier:

PDF, 1.60 MB

english, 2010

Structural insights into Parkin substrate lysine targeting from minimal Miro substrates

Klosowiak, Julian L., Park, Sungjin, Smith, Kyle P., French, Michael E., Focia, Pamela J., Freymann, Douglas M., Rice, Sarah E.

Journal:

Scientific Reports

Année:

2016

Langue:

english

Fichier:

PDF, 1.61 MB

english, 2016

The Two GTPase Domains of the Outer Mitochondrial Membrane Protein Miro have Novel Active Site Conformations and Distinct Biochemical Properties

Smith, Kyle P., Focia, Pamela J., Zhang, Yongbo, Klosowiak, Julian L., Freymann, Douglas M., Rice, Sarah E.

Journal:

Biophysical Journal

Année:

2017

Langue:

english

Fichier:

PDF, 66 KB

english, 2017

DNA-Directed Protein Packing within Single Crystals

Winegar, Peter H., Hayes, Oliver G., McMillan, Janet R., Figg, C. Adrian, Focia, Pamela J., Mirkin, Chad A.

Journal:

CheM

Année:

2020

Fichier:

PDF, 2.58 MB

2020

Insight into human Miro1/2 domain organization based on the structure of its N-terminal GTPase

Smith, Kyle P., Focia, Pamela J., Chakravarthy, Srinivas, Landahl, Eric C., Klosowiak, Julian L., Rice, Sarah E., Freymann, Douglas M.

Journal:

Journal of Structural Biology

Année:

2020

Fichier:

PDF, 4.83 MB

2020